diff --git a/gnu/packages/qt.scm b/gnu/packages/qt.scm
index 3fa2db546c3..66876fffd29 100644
--- a/gnu/packages/qt.scm
+++ b/gnu/packages/qt.scm
@@ -4108,8 +4108,20 @@ (define-public qtwebengine
                 (("/usr/share/X11/xkb")
                  (search-input-directory inputs "share/X11/xkb")))
               ;; Substitute full dynamic library path for vulkan-loader.
-              (substitute* '("src/core/compositor/vulkan_implementation_qt.cpp")
-                (("libvulkan.so.1")
+              (with-directory-excursion "src/3rdparty/chromium"
+                (substitute*
+                  '("third_party/vulkan-headers/src/include/vulkan/vulkan.hpp"
+                    "third_party/swiftshader/include/vulkan/vulkan.hpp"
+                    "third_party/angle/src/third_party/volk/volk.c"
+                    "media/gpu/sandbox/hardware_video_encoding_sandbox_hook_linux.cc"
+                    "content/common/gpu_pre_sandbox_hook_linux.cc"
+                    )
+                  (("dlopen\\( ?\"libvulkan.so")
+                   (string-append "dlopen(\""
+                                  (search-input-file
+                                    inputs "/lib/libvulkan.so")))))
+              (substitute* "src/core/compositor/vulkan_implementation_qt.cpp"
+                (("libvulkan\\.so\\.1")
                  (search-input-file inputs "lib/libvulkan.so.1")))))
           (add-before 'configure 'prepare-build-environment
             (lambda _